MECHANISMS OF DERMATOPHYTE RESISTANCE TO ANTIFUNGAL SUBSTANCES
نویسندگان
چکیده
منابع مشابه
Mechanisms of antifungal resistance
The many drugs that are available at present to treat fungal infections can be divided into four broad groups on the basis of their mechanism of action. These antifungal agents either inhibit macromolecule synthesis (flucytosine), impair membrane barrier function (polyenes), inhibit ergosterol synthesis (allylamines, thiocarbamates, azole derivatives, morpholines), or interact with microtubules...
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Failure to respond to antifungal therapy could be due to in vitro resistance (intrinsic or developed during therapy) or clinical resistance; the latter is associated with numerous factors related to the host, the antifungal agent, or the infecting isolate. Recently, a susceptible MIC breakpoint ( < or =2 microg/ml) was designed for Candida spp. to all three available echinocandins, anidulafungi...
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Superficial dermatophytoses are among the most common infectious disease. The most commonly used antifungal categories reazoles, polyenes and echinocandins. Due to the limited number of available antifungal drugs, toxicity and the emergence of resistant (intrinsic or acquired) strains, antifungal strategy needs to be developed. Recently the researchers try to find alternative antifungal agents....
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Fungal pathogens are using several mechanisms to circumvent the inhibitory actions of antifungal drugs. The variety of these mechanisms was revealed in recent years by several laboratories with molecular approaches. Besides the identification of genes involved in antifungal drug resistance and the discovery of alternative pathways of resistance (i.e. biofilm formation), novel concepts in the un...
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Fungi, especially the filamentous types, have become definitely established as the most important group of organisms that is capable of producing antibacterial substances under proper conditions of culture. No less significant, even if less well known, is the fact that many microorganisms, including fungi on the one hand, and bacteria and actinomycetes on the other, are capable of producing age...
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ژورنال
عنوان ژورنال: Postępy Mikrobiologii - Advancements of Microbiology
سال: 2020
ISSN: 0079-4252,2545-3149
DOI: 10.21307/pm-2020.59.2.012